Precautions No.

Precautions

1

Podophyllin should be applied only by the physician.

2

The drug should be applied only to small areas of intact skin. Biopsies if taken, should be allowed to heal completely before the application of podophyllin.

3

Alcohol should be avoided before and for several hours after the application. General anaesthesia and central nervous system depressant drugs should be avoided.

4

The drug should be avoided in the oral cavity.

5

It should not be used in pregnant women.

6

Initially, a test application should be left on for a period of one hour. If there is no irritation, subsequent applications should be allowed to remain for 4 - 6 hours.

7

The volume of liquid applied should be kept to the minimum (von Krogh [44] recommends a volume not exceeding 0.4 - 0.5 ml for P. emodi based podophyllin and 0.9 -1.2 nil for P. peltatum based podophyllin).

8

The drug should be stored in narrow-mouthed bottles, otherwise undue evaporation might lead to an increased concentration of podophyllin. Preparations containing a sludge or precipitate and old, dried, gritty preparations should be discarded.