Precautions No. | Precautions |
1 | Podophyllin should be applied only by the physician. |
2 | The drug should be applied only to small areas of intact skin. Biopsies if taken, should be allowed to heal completely before the application of podophyllin. |
3 | Alcohol should be avoided before and for several hours after the application. General anaesthesia and central nervous system depressant drugs should be avoided. |
4 | The drug should be avoided in the oral cavity. |
5 | It should not be used in pregnant women. |
6 | Initially, a test application should be left on for a period of one hour. If there is no irritation, subsequent applications should be allowed to remain for 4 - 6 hours. |
7 | The volume of liquid applied should be kept to the minimum (von Krogh [44] recommends a volume not exceeding 0.4 - 0.5 ml for P. emodi based podophyllin and 0.9 -1.2 nil for P. peltatum based podophyllin). |
8 | The drug should be stored in narrow-mouthed bottles, otherwise undue evaporation might lead to an increased concentration of podophyllin. Preparations containing a sludge or precipitate and old, dried, gritty preparations should be discarded. |